They're different.: Clindamycin is an antibiotic that is not commonly used for initial treatment of sinusitis. Mucinex (guaifenesin) is a medication that may help you because it loosens thick mucus. Also try a decongestant like pseudoephedrine (e.g., Sudafed) and saline sinus rinses for best results. It is not recommended to start antibiotics for sinusitis unless not improving after 7 days.
Answered 4/4/2015
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