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A member asked:
Tumor cells do not show significant nuclear pleomorphism, does this mean malignancy or benign?
A doctor has provided 1 answer
Low grade: Pleomorphism is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and/or their nuclei. It is a characteristic of malignant neoplasms, and metaplasia. Certain benign cellS tmay have pleomorphism, e.g. neuroendocrine cells, Newer techniques with mAbs targeting tumor protein can identify transformation even before nuclear pleomorphism seen.
Answered 11/23/2014
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