Do statins have any role in increasing serum creatinine? i well controlled dm type2 on oral antidiabetics and hypertension controlled ca channel block

Maybe at high doses: LIMITED data has suggested that statins at higher doses, i.e. more than 40 mg simvastatin a day, might contribute to acute renal failure. This is counter intuitive because, in general, the effects of statins would be very favorable for those at risk for renal failure, such as yourself, with Type2 DM & hypertension. Most experts still recommend statins in this situation unless pt on dialysis.