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Walnut Creek, CA
A 22-year-old female asked:

Is it dangerous to take zoloft 45 and paxil (paroxetine) 20 if i half them and take it together to transition? dr didn't tell me anything about serotonin syndrome.

1 doctor answer1 doctor weighed in
Dr. Saptarshi Bandyopadhyay
Hospital-based practice 22 years experience
Long half-life.: Both of these medications have a very long half-life so they will be in your body even if you stop them abruptly. Also, meds take ~4.5 half-lives (with regular dosing) before they are "steady state" effective (it depends on the exact drug & its "kinetics"). Less than 0.1% get serotonin syndrome (hard to say who). No prob stopping 1 SSRI & starting the other. Follow-up with your doctor/psychiatrist
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Last updated Mar 16, 2021


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