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A 40-year-old member asked:

Can you take paxil (paroxetine) and zoloft together?

2 doctor answers5 doctors weighed in
Dr. Jane Steiner
Psychiatry 43 years experience
Don't take together: You may not feel very good. You don't need to take both from the point of view of helping with depression, as they work in a very similar way on serotonin.Taking them together could cause unpleasant symptoms of jitteriness and anxiety called "serotonin syndrome".
Dr. Donald Jacobson
A Verified Doctor commented
A US doctor answered Learn more
You may take them together if you are transitioning from 1 to the other. I have one severe OCD patient who has been on them successfully for years, but I agree, there is rare risk of serotonin syndrome so doing this should be rare and limited to transitional periods.
Oct 25, 2013
Dr. Jane Steiner
Psychiatry 43 years experience
Provided original answer
That's true that you may be on both when transitioning from one to the other. That is the best way to make a switch.
Oct 25, 2013
Dr. Heidi Fowler
Psychiatry 25 years experience
SSRI's: If you were in the middle of a cross titration from one drug to the other, that would make sense. Otherwise, I don't understand why you would be taking two SSRI's.

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Similar questions

A 36-year-old member asked:

Could Paxil (paroxetine) and Zoloft be taken together?

3 doctor answers7 doctors weighed in
Dr. Pamela Pappas
Psychiatry 42 years experience
Why?: I'm wondering why you'd want to take 2 drugs in the same class? Depending on the doses of each, it could result in serotonin syndrome. I recommend against this.
A 47-year-old member asked:

What will happen if you take Zoloft and Paxil (paroxetine) at the same time?

1 doctor answer1 doctor weighed in
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Zoloft/paxil: Not advised, since both raise serotonin in your body and can trigger serotonin syndrome.

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Last updated Jul 4, 2020

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