A 47-year-old member asked:
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Can you take Paxil (paroxetine) and Zoloft together?

1 doctor answer
Dr. Jane Steiner
42 years experience in Psychiatry
Don't take together: You may not feel very good. You don't need to take both from the point of view of helping with depression, as they work in a very similar way on serotonin.Taking them together could cause unpleasant symptoms of jitteriness and anxiety called "serotonin syndrome".
Answered on Mar 28, 2019
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Dr. Donald Jacobson
39 years experience in Psychiatry
You may take them together if you are transitioning from 1 to the other. I have one severe OCD patient who has been on them successfully for years, but I agree, there is rare risk of serotonin syndrome so doing this should be rare and limited to transitional periods.
Oct 25, 2013
Dr. Jane Steiner
42 years experience in Psychiatry
Provided original answer
That's true that you may be on both when transitioning from one to the other. That is the best way to make a switch.
Oct 25, 2013

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A 28-year-old female asked:
Dr. Saptarshi Bandyopadhyay
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Long half-life.: Both of these medications have a very long half-life so they will be in your body even if you stop them abruptly. Also, meds take ~4.5 half-lives (wit ... Read More
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A 28-year-old female asked:
Dr. Olav Jaren
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Switching Rx: That dose of paxil (paroxetine) is not very high, and it's possible you could make the switch. The zoloft should help take its place. If you have an ... Read More
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A 43-year-old member asked:
Dr. Pamela Pappas
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Why?: I'm wondering why you'd want to take 2 drugs in the same class? Depending on the doses of each, it could result in serotonin syndrome. I recommend a ... Read More
A 55-year-old member asked:
Dr. Alan Ali
Dr. Alan Ali answered
31 years experience in Psychiatry
Zoloft/paxil: Not advised, since both raise serotonin in your body and can trigger serotonin syndrome.
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