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Port Neches, TX
A 36-year-old male asked:

Will nexium (esomeprazole) work in 24 hours like prilosec ? prilosec works good but constipates me.which one works faster bec i can't wait 3 days for nexium (esomeprazole)

2 doctor answers4 doctors weighed in
Dr. Timothy Puri
Internal Medicine 12 years experience
No: Nexium (esomeprazole) can take up to 30 days to fully have an effect on your symptoms. You should take it even when you are not having them if your doctor tells you that you need to be on them.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Alan Kelly
Dr. Alan Kelly commented
Internal Medicine 28 years experience
You are going to prob see an improvement in a day or two. The pharmacokinetics of Prilosec & Nexium are very similar. They are just different forms of each other (different isomers). They both have a half life of 1.5-3 hrs, so your stomach acid pumps will be suppressed within a day or two. It may take days or weeks for the tissue to heal if you have an ulcer or esophagitis. Go try the Nexium
Aug 17, 2014
Dr. William Lages
Internal Medicine - Rheumatology 69 years experience
No: Both Nexium (esomeprazole) and Prilosec are proton pump inhibitors and very closely related. They take days to weeks to be fully effective. If you need relief in 24 hours you need to take an H2 blocker like Pepcid. If your doctor thinks you need.long term proton pump inhibitor to prevent GERD complications you should discuss with him and not treat yourself.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Sep 19, 2016


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