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A member asked:
How does cymbalta (duloxetine) work differently from gabapentin for cipn?
A doctor has provided 1 answer
Different mechanism: Chemotherapy-induced peripheral neuropathy (CIPN) are often treated with neuropathic medicine (e.g. Gabapentin) or selective serotonin and norepinephrine reuptake inhibitor (Cymbalta/Duloxetine). Gabapentin works by mimic GABA receptors (mainly inhibitory receptors) in the synaptic pathway, reduce excitation of neurons. Duloxetine is believe to inhibit pro-inflammatory cytokines in the brain.
Answered 4/29/2018
3.8k views
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