Is it normal to have a feel of "carelesness" and "emptiness" while on seroquel-lithium? doc says that that is up to me to feel better? advice?

Depression: Multiple issues at work here: depression, anxiety, underlying medical issues- get an immediate second opinion.

One possibility is: that you may feel relatively "empty" if your emotional highs and lows have been tempered by seroquel (quetiapine) and lithium. Life may feel bland without these ebbs & flows - and it may take a while to adjust to it. As far as you feeling better - it may take lots of work. I wish you well.