Can i take prilosec omeprazole for life time? is it safe to take it since am taking 2000 mg daily of naproxen for osteoarthritis ?

Yes and ??: The complications associated with prolong PPI ingestion are mainly consequences of the reduction of stomach acid. This raised the possibility of GI infections like food poisoning. Also, you will probably have poor absorbtion of some minerals like Calcium and Magnesium. You should discuss these issues with your doctor.

Yes,but: Omeprazole and other proton pump inhibitors markedly decrease stomach acid so you would need to take supplemental calcium, and vitamins B12 and D to prevent osteoporosis and B12 deficiency. 2000mg of Naproxen is a lot and it might be good to take less plus a pain med but not aspirin.Talk to your doctor about this.

Yes and no!: First, Naproxen 2000 mg per day is a stiff dose for your gut! The FDA does not approve dosage! Maybe this portrays why your "gut" is hurting. There are numerous long term side effects of proton pump blockers, such as you are on. One is a type of habituation, since the longer taken, the harder to get off the omeprazole. Numerous nutritional concerns exist. Generic Arthrotec and Celebrex (celecoxib) exist!

Yes: Yes, it is safe. However, it is not ideal. Chronic suppression of stomach acid may cause increase gastrin levels and potentially increase the incidence of Gastrinomas ( theoretically ). You should look for other ways to treat osteoarthritis.

When the proton pump: inhibitors were first introduced we were told that long term use was not recommended. However it is now a drug that has been used by patients for a longer period of time to relieve the symptoms of gerd. In your case I would be more worried about the long term use of Naproxen. It can cause GI bleeding, & long term use may cause cardiac problems.