If saphris (asenapine) was working 1st 3 weeks on 10mgs, then symptoms got worse than b4 being on it, then increased to 15mgs, when will it get better?

1-2 weeks: While there are no good studies to accurately answer your question, it seems with some patients that a week or two on an increased dose would be an appropriate amount of time to assess whether it is helping or not. If you continue to feel worse, however, you need to tell your prescribing doctor right away. It's possible this may not be the right drug for you and want to make sure you're safe.