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A 23-year-old female asked:

I have major depression and i do high intensity intervals workout.if i take 5 grs of creatine each day, it helps to reduce my depression?weight gain?

2 doctor answers4 doctors weighed in
Dr. Mohammed Karim
Internal Medicine 30 years experience
Unknown: Creatine is a popular supplement & it will increase your muscle mass & body weight. There is a small published study claimed that 5 Gms of daily creatinine will help in depression. Data on this matter are insufficient and needs more study. At present no FDA recommendation. Check your kidney function and CPK regularly if you to take it. Above all talk to your PCP about it.
Dr. Dariush Saghafi
Neurology 34 years experience
Not enough evidence: According to the National Institute of Health there is insufficient evidence to rate the effectiveness of creatine as it applies to the treatment of depressive symptoms. When used at recommended doses the substance is rated as POSSIBLY SAFE. When exceeding these doses it is rated as POSSIBLY UNSAFE. Here is a link you may find useful: http://www.nlm.nih.gov/medlineplus/druginfo/natural/873.html

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Last updated Jul 20, 2014


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