A member asked:

I was wondering what would happen if i went cold turkey off clozapine?

6 doctors weighed in across 3 answers

Shouldnt: you shouldn't, if you do, you end up with a rebound of symptoms that can sometimes be harder to treat. consult with your prescriber

Answered 5/7/2016

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Dr. Anthony Vita answered

Specializes in Psychiatry

DO NOT DO THIS: I agree with the previous physician's comments. Withdrawal from clozapine is horrible, with serious physical symptoms. In addition, whatever psychiatric symptoms the clozapine is treating could come back. if you want to get off of clozapine talk to your psychiatrist and taper off with his/her guidance.

Answered 7/4/2014

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Dr. Humberto Quintana answered

Specializes in Psychiatry

Not recommended: Clozapine is usually used only in patients that have not responded to other anti-psychotic treatments due to its danger of causing agranulocytosis as well as the costs of having to have blood tests continually during treatment. Abrupt withdrawal may lead to cholinergic rebound effects, severe movement disorders as well as severe psychotic decompensation. It has been recommended that patients, families, and caregivers are aware of the symptoms and risks of abrupt withdrawal of clozapine. When discontinuing clozapine, gradual dose reduction is recommended to reduce the intensity of withdrawal effects

Answered 1/16/2016

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