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NJ
A 28-year-old female asked:

26 y/o-- iga- 40ml/dl, igg- 1325ml/dl, igm- 111ml/dl. iga is the only low ig. could this be cvid? wouldn't i have low igg as well?

2 doctor answers5 doctors weighed in
Dr. John Chiu
Dr. John Chiu answered
Allergy and Immunology 57 years experience
Don't worry: Isolated low IgA occurs in about 1/500 people. If it is the only immunoglobulin being low, i won't be concerned over it.
Dr. Michael Palumbo
Allergy and Immunology 23 years experience
Not necessarily: Need to also look at antibody titers to diphtheria, tetanus and pneumococcus. Can have normal IgG numbers with abnormal function and thus low antibody response which would also be CVID.

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Similar questions

CA
A 27-year-old member asked:

What does it mean that I have a low IgM level?

3 doctor answers11 doctors weighed in
Dr. Alex Martinez
Specializes in Allergy
?immune deficiency: Igm is the first antibody made as infections begin; in the circulation, 5 antibodies are usually connected together and when activated, they do a particularly good job at announcing an early infection. Low IgM by itself is rarely seen; when other antibodies (igg, iga) are also low, it could mean an immune deficiency of some kind. Consulting an immunologist can help in determining the cause.
Dr. Jack Mutnick
Allergy and Immunology 17 years experience
This is an EXCELLENT answer and could not have been stated better. See an Immunologist for further work up.
Jan 14, 2012
A 35-year-old member asked:

What does it mean if IgM and IgA levels drop lower?

1 doctor answer1 doctor weighed in
Dr. Barbara Stark Baxter
Allergy and Immunology 42 years experience
IgM and IgA: Low levels of IgA and IgM may mean that you have an immune deficiency. If they are only slightly low and your igg is normal and you are able to respond to vaccines and do not have a lot of infections, there may be nothing to worry about. We need a lot of history and additional blood tests to understand what any particular level of antibodies in the blood means.
A 46-year-old member asked:

What does it mean to have a positive IgM but a negative IgG for mycoplasm?

1 doctor answer2 doctors weighed in
Dr. James Ferguson
Pediatrics 46 years experience
Early vs late: Igm is the immunoglobulin noted for coming out early in response to any illness, it fades over time while igg come out a bit later and stays up longer. If you have a positive IgM it indicates a early response, while igg would probably show up in a few months at which point the IgM would have declined.
A 45-year-old member asked:

When should a IgG vs a IgM test be ordered?

1 doctor answer2 doctors weighed in
Dr. Michael P Vaughn
Allergy and Immunology 34 years experience
IgM vs. IgG: Igm tests are typically ordered when an infection is thought to be present for one week or more. Igm levels often disappear within the first few months. Igg testing is typically ordered when the infection has been thought to be present for 2 or more weeks. Igg levels my stay elevated for years after an infection has resolved.
A 38-year-old member asked:

What do elevated levels of IgM mean?

1 doctor answer1 doctor weighed in
Dr. Gary Steven
Pediatric Allergy and Asthma 30 years experience
Depends: The "normal ranges" for all lab tests include 95% of the "normal" population; thus, 2.5% of people are above the upper limit, and 2.5% are below the lower limit. There's nothing to worry about if your values are a little bit above the normal range, but a very elevated IgM could be a sign of a problem. You need to check with the physician who ordered the tests to interpret your results.

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Last updated Mar 19, 2017
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