Can you please tell me how safe is the nardil, (phenelzine) mellaril, and norpramin medication?

Somewhat depends: All three have been used for more than 40 years. Nardil needs to be taken in context of care diet modification, but it works quite well. Mellaril is an antipsychotic used for years and years, until eli lilly got scared of Geodon (ziprasidone) and forced the fda to study other antipsychotics for qtc changes. Again, quite safe. Norpramin is despiramine, one of the first antidepressants; again, used for years.