Is desipramine a better antidepressant than nardil (phenelzine) for motivation?

Depends: Desipramine is an old medication from the tca group. It is relatively norepinergic, that can possibly increase motivation. Nardil (phenelzine) belongs to the group of maoi, which are supposed to increase all three neurotransmitters, promote alertness etc., which also can improve motivation. I normally let my patients to try both and choose. (nb! cannot be taken in the same time!).