Are there any medications that can make gerd worse?

Yes: Gerd can be exacerbated by many different drugs, including anticholinergics, beta blockers, bronchodilators used for asthma, calcium channel blockers, Dopamine agonists, sedatives, and tricyclic anti-depressants. It is best to talk with your physician if you are on other medications to see if they may cause your gerd symptoms to worsen.

Aspirin and nsaids: Non-steroidal anti-inflammatory drugs and Aspirin (un-coated) all can cause gastric irritation (stomach bleeds) which can have an adverse effect on gastro-esophogeal reflux disease. There are many good acid reducers on the market-(blockers and buffers) that can offset the problems if a medical condition requires their use (nsaids- for arthritis).