A member asked:

What is the difference between ssri's and snri's? is remeron (mirtazapine) considered either of these?

4 doctors weighed in across 2 answers

SSRI vs SNRI: Remeron (mirtazapine) is a noradrenergic and specific serotonergic antidepressant nassa. An ssri is a selective serotonin reuptake inhibitor and an snri is a serotonin and norepinephrine reuptake inhibitor. The difference is that the latter increases both serotonin and norepinephrine in the synaptic clefts of the mood regulating limbic system while an ssri only increases serotonin. Best wishes and happy thanksgiving.

Answered 6/30/2014

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Dr. Charles Turck answered

Specializes in Pharmacology

See below : They affect different chemicals in the brain: SSRIs affect serotonin and SNRIs affect serotonin and norepinephrine receptors. Remeron does not fall into either of these categories as it affects others: serotonin, histamine, alpha and muscarinic receptors. However, SSRIs, SNRIs, and Remeron are used to treat similar conditions, despite the different ways they affect the body’s chemicals.

Answered 10/14/2019

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