Can i take oxymetazoline nasal spray and pseudophedrine together?

Yes, short term: Oxymetazoline is a nasal decongestant spray that works quickly to decrease stuffy nose, but if used beyond 4-7 days may result in "rebound" nasal congestion and a person can become dependent upon it. Pseudoephedrine is an oral decongestant that is effective but has multiple side effects including increasing BP in those with hard to control high blood pressure, insomnia, dry mouth, and GI upset.