Question 1

how is vincristine used?

Accepted Answer

Chemotherapy: Variety of cancers, leukemias...Acts by affecting microtubules....

Question 2

what does vincristine do?

Accepted Answer

Vinca alkaloid: It interferes with the growth of cancer cells and slows their spread in the body by binding to tubulin and inhibit microtubule formation in cancer cells and arresting cancer cell growth.

Question 3

alternatives to vincristine?

Accepted Answer

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves.  Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. The alternative is vinblastine.

Question 4

which is more prefered vincristine or vinblastin sulfate?

Accepted Answer

They are in the same: Class but not interchangeable. Vcr is used in many pediatric diseases in combination. It causes constipation in that age group. It used to be used in brca (cmf-vp) and many adult lymphoma. Vbl is used in hd, testis cancer as part of curative regimens. It is also used as a single agent in lung and breast for symptom relief.

Question 5

why does vincristine have side effects like nerve problems?

Accepted Answer

Microtubules!: Vincristine stops the formation of microtubules, which are important in cell division (leading to nausea, low blood counts, hair loss, etc.) but microtubules ALSO transport chemicals inside our nerve cells. The longest nerves in our body connect our spinal cord to our fingertips and toes ; this is why vincristine causes nerve problems especially in fingertips and toes.

Question 6

how can the chemo therapy drug vincristine be harmful?

Accepted Answer

Neurotoxicity: The major dose limiting toxicity of vincristine is neuropathy.  There are other "usual" chemo side effects including bone marrow suppression -- lowering wbc, rbc, PLT -- but neurotoxicity is the one we watch for the most.

Question 7

please tell me what can be done with vincristine or vinblastine encephalopathy?

Accepted Answer

Your doctor can addr: This should be addressed by your doctor . I need to know more about the circumstances which lead to this problem. It is not a condition which happens easily unless there was an accidental overdose of medication(vincristine, more often than vinblastine).
Is the affected person functional or non functional due to encephalopathy? Tell me some more.

Question 8

why vincristine is one of the most used cancer drug?

Accepted Answer

While it one of: The oldest anti-cancers, it has no marrow suppressive effecs. As a vinca alkaloid, it interferes with the mitotic spindle formation necessary for actively dividing cells. It is used in many pediatric tumors as a cornerstone drug. Leukemias and lymphomas.  It does not work very well in most adult solid tumors.

Question 9

i am getting vincristine and dactinomycin andi want to lessen the side effects?

Accepted Answer

These remain: Cornerstone drugs in wilms tumor and other pediatric tumors. All drugs have side effects. Speak to your oncologist about which one bothers you the most. The usual answer is dose reduction or substitution of another drug...Neither good options.

Question 10

how can vincristine and doxorubicin be fatal to a cell?

Accepted Answer

They are/Bind to nuc: They bind to nuclear elements and stop dna synthesis which leads to cell death.

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Doctor answers about:

Vincristine

A member asked:

How is vincristine used?

A member asked:

What does vincristine do?

A member asked:

Alternatives to vincristine?

A member asked:

Which is more prefered vincristine or vinblastin sulfate?

A member asked:

Why does vincristine have side effects like nerve problems?

A member asked:

How can the chemo therapy drug vincristine be harmful?

A member asked:

Please tell me what can be done with vincristine or vinblastine encephalopathy?

A member asked:

Why vincristine is one of the most used cancer drug?

A member asked:

I am getting vincristine and dactinomycin andi want to lessen the side effects?

A member asked:

How can vincristine and doxorubicin be fatal to a cell?

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