alternatives to vincristine?

Question

How can the chemo therapy drug vincristine be harmful?

Answer 1

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. The alternative is vinblastine.

Answer 2

Depends on cancer: Alternative to vincristine -will depend on the type of cancer. Different cancer has different treatment. Please discuss with your oncologist in detail about your options etc. Good luck.

Answer 3

Vinca alkaloid: It interferes with the growth of cancer cells and slows their spread in the body by binding to tubulin and inhibit microtubule formation in cancer cells and arresting cancer cell growth.

Answer 4

Vincristine ...: Blockscell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. As such, t blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons.

Answer 5

Chemotherapy: Variety of cancers, leukemias...Acts by affecting microtubules....

Answer 6

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid.

Answer 7

Chemo agent: Vincristine is a chemotherapeutic agent also known as Oncovin (vincristine). It is primarily employed in the treatment of lymphomas and Hodgkins disease, usually in combination with other drugs such as in CHOPP. Side effects include nausea, hair loss and neurologic loss of balance. It works partly by binding to the tubulin protein, stopping the cell from separating its chromosomes during metaphase

Answer 8

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs.

Answer 9

Vincristine ...: Blocks cell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. Thus, it blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons.

Answer 10

Lots of uses: Used in multiple malignancies but also used in non-malignant hematologic (blood) disorders, such as itp (immune mediated thrombocytopenia). This is low platelets. Hope this helps.

Answer 11

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid.

alternatives to vincristine?

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