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A 24-year-old male asked:

How long would the rpr syphilis test be accurate after infection. would it be accurate between 1-2 years after exposure or is it less reliable then?

2 doctor answers2 doctors weighed in
Dr. Ed Friedlander
Pathology 45 years experience
NEVER realiable: The RPR is never a "reliable" test for syphilis. It is only a screen. If you have any concern that you have syphilis, get with your physician for more accurate testing.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Hunter Handsfield
Infectious Disease 54 years experience
Very reliable: First, RPR is no longer the usual first blood test for syphilis. Most labs now start with an IgG ELISA. Either this or RPR is always positive within 6 weeks. In other words, a negative test more than 6 weeks after the last posssible exposure, including 1-2 years, proves you do not have active syphilis. However, a positive results isn't necessarily reliable; positives require confirmatory testing.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Feb 7, 2021

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