NY
A 24-year-old male asked:

How long would the rpr syphilis test be accurate after infection. would it be accurate between 1-2 years after exposure or is it less reliable then?

2 doctor answers2 doctors weighed in
Dr. Ed Friedlander
Pathology 46 years experience
NEVER realiable: The RPR is never a "reliable" test for syphilis. It is only a screen. If you have any concern that you have syphilis, get with your physician for more accurate testing.
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Dr. Hunter Handsfield
Infectious Disease 55 years experience
Very reliable: First, RPR is no longer the usual first blood test for syphilis. Most labs now start with an IgG ELISA. Either this or RPR is always positive within 6 weeks. In other words, a negative test more than 6 weeks after the last posssible exposure, including 1-2 years, proves you do not have active syphilis. However, a positive results isn't necessarily reliable; positives require confirmatory testing.
Created for people with ongoing healthcare needs but benefits everyone.

Related questions

A 23-year-old male asked:
STD Expert: How accurate/conclusive is a syphilis test at 8 weeks past potential exposure? This is the test name: RPR (DX) W/REFL TITER AND CONFIRMATORY TESTING. Test came back negative?
Dr. Hunter Handsfield
Infectious Disease 55 years experience
100% conclusive. You can be sure you do not have syphilis.
Created for people with ongoing healthcare needs but benefits everyone.
A 22-year-old male asked:
How soon can I test for syphilis, HPV, HSV without any symptom? I had RPR blood test for syphilis at 19 days after exposure, and HPV Genotype PCR and HSV 1/2 PCR test at 26th (all using penile urethra swab), all negative. How reliable are those?
Dr. Birendra Tandan
Urology 36 years experience
Reliable within the limits of each test( all tests can have false neg and positive results). Syphilis test may be repeated in 5-6 weeks
Created for people with ongoing healthcare needs but benefits everyone.
A 23-year-old male asked:
Tested negative for Chlamydia + Gonorrhea (PCR), Syphilis (RPR), HIV (4th gen Combo), HSV (IgG and IgM blood test), Hep B and Hep C 96 days after exposure? Am I safe? Are those tests clinically conclusive every single one of them?
Dr. Birendra Tandan
Urology 36 years experience
Within the range of accuracy of the tests =you are. Like life- no test is 100%. But negativity here is good news
Created for people with ongoing healthcare needs but benefits everyone.
A 37-year-old male asked:
How accurate would an RPR Syphilis test be at 5.5 wk post-exposure (protected oral w high risk person)? Mild rash on chest and face at time of test and ulcer on scrotum 3 weeks post-exp but I have HSV2. Had z pack 2 weeks post for unrelated infec?
Dr. Gurmukh Singh
Pathology 51 years experience
Visit these sites for information on this topic: Syphilis window period: https://www.e7health.com/post/155/std-test-window-when-should-i-get-tested/#:... Read More
Created for people with ongoing healthcare needs but benefits everyone.
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A 33-year-old male asked:
Dr Syphilis question exposure April 1 tested RPR neg at june 2, 54 days but was on z pak a day before then due to antibiotics thought to test again, RPR test again aug 2 120 days its conclusive? Thanks?
Dr. Hiep Le
Dr. Hiep Leanswered
Nephrology and Dialysis 44 years experience
Azithromycin on day 53rd should not affect the RPR result one day later so the test on day 54th should be conclusive. Assume you did not have RPR test... Read More
Created for people with ongoing healthcare needs but benefits everyone.
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Last updated Feb 7, 2021

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