A 66-year-old female asked:
2 opinions on estradiol cream for vaginal atrophy. gyne prescribed it 3x a week and said risk of uterine cancer very low. my physicians assistant at my gp said i must take oral progesterone with it or my endometrium will thicken. who is right?
2 doctor answers • 2 doctors weighed in
Dr. John Berrymananswered
Obstetrics and Gynecology 56 years experience
Gradual bloodstream levels of estrogen by strictly vaginal use of estrogen sources , and can cause proliferation of endometrial cells. Long term use may be managed by your prescribing physician by occasional ultrasound imaging of the endometrial lining. If the lining is equal to one cm. in depth, a biopsy may be indicated.
Answered May 02, 2022
Dr. Hiep Leanswered
Nephrology and Dialysis 44 years experience
You should trust your GYN more.
Reviewed May 03, 2022
Last updated May 3, 2022
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