Syphilis treatment: Why not long-acting penicillin? It's the treatment or choice world-wide, unless severe penicillin allergy. Some syphilis is resistant to erythromycin and related drugs, very common throughout Europe. However, doxycycline is effective if taken reliably for 2 weeks (100 mg twice daily). Symptoms may take longer to clear up, however. If you remain uncertain, check back with your doctor.
Answered 2/25/2021
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