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A 24-year-old female asked:

I was tested for syphilis. rpr was pisitive(1:1) and tppa was negative. does in mean i am infected?

1 doctor answer1 doctor weighed in
Dr. Martin Raff
Infectious Disease 57 years experience
Syphilis: Probably not. The RPR is a screening test which is very sensitive but not as specific, so that you can have false-positive results. The TPPA is far more specific and used to detect the RPR positives that are falsely positive.
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Last updated Aug 6, 2020

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