Is it better to take zoloft (sertraline) in am or pm?

Neither: It's more important to take sertraline at a consistent time that works for you. If it's easier to remember to take in the am, then consistently take it every am.

That depends: If you are one of the upto 13% of people that develop somnolence on zoloft would take it in pm. if it has a stimulating effecti take in am. Most people will not feel tired or more awake on it - so they can take at any time of day. Try to take at same time each day.