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A 48-year-old member asked:

Is it true that you shouldn't take ibuprofen if you are on zoloft (sertraline)?

3 doctor answers9 doctors weighed in
Dr. Andrew Oswari
Family Medicine 24 years experience
Technically: Technically there is an interaction between nsaids and zoloft. Celebrex (celecoxib) is safe to take with it though.
Dr. Peter Corrado
Family Medicine 41 years experience
Yes: Zoloft (sertraline) may increase the side effects of Ibuprofen leading to increased bleeding. In addition, Ibuprofen may decrease the effectiveness of zoloft (sertraline). Not a good combination.
Dr. Kevin Nasky
Psychiatry 16 years experience
Not necessarily.: In general, not a problem to take both. I believe there is a moderate risk of gastrointenstinal bleeding when both ssris and nsaids are taken chronically (i.e. Every day), though i don't think there's any research showing significant risk of occasional NSAID use in patients taking ssris. It would be important to know what other GI bleeding risks you have, if any.

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Last updated Jun 27, 2017

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