Can wellbutrin (bupropion) cancel out the weight gain side effect of celexa?

Possibly: Doctors often combine medications in a way to maximize their benefits and minimize their side effects. What matters, is does this work for you?

To some degree: Wellbutrin, (bupropion) in most cases, either decreases appetite or has no effect on it. The most important way to avoid weight gain is a healthy balanced diet and exercise. Celexa may increase appetite but it is the number of calories consumed and not spent daily is what causes the weight gain.