I had stage iii-b colon cancer and the tumor was removed surgically. i went to 2 oncologists who suggested different chemos: folfox vs. capeox. i know that folfox is the standard. does this mean it's better?

Equivalent choices: Capox is really an equivalent regimen to folfox. The difference is that the folfox regimen uses a drug (5- fluorouracil) that is given intravenously via a pump, wile the other regimen utilizes Capecitabine which is an oral version of the same drug which is activated preferentially in the tumor cells. There is a slight difference in the schedule, but these are really considered interchangeable.

Likely equivalent: Folfox is standard based on mosaic trial. Capeox non-inferior to folfox in stage 4 colorectal cancer based on trials. Randomized phase 3 trial comparing adjuvant folfox vs capeox completed, with safety demonstrated. Efficacy to be reported in near future. Most oncologists would accept either. Purists will wait for trial data. Should consider current trial comparing 3 vs 6 mths of folfox.

Similar: Both have oxaliplatin. Fol fox uses a 5-fu infusion and leucovorin. Capeiox uses capecitibine called xeloda (capecitabine). This pill is changed in tumors to 5-fu. Both are effective, but some insurances prefer the cheaper folfox.

Either is good: There is no absolute right answer as there are a variety of factors that oncologists evaluate before recommending a particular chemotherapy regimen. Both are good but have differing toxicities which you should have clearly outlined by your oncologist. You should definitely chose an oncogist with whom you feel comfortable.