Can a nuclear stress test cause you problems?

Typically not: The only "risk" would be during the stress part, when one runs on a treadmill or gets a drug alternative. However, there is little risk here because this is monitored with an ekg and supervised by a cardiologist/nuclear physician. One drug that is used for stress even has an agent that can reverse its side effects. In summary, under normal standard-of care-conditions, there should be little risk.