A member asked:

Can i take macana puriens (cowhage) while on prozac (fluoxetine)?

4 doctors weighed in across 3 answers

Not advisable: Leaves of m. Pruriens contain l-dopa, a precursor to the neurotransmitter dopamine. The l-dopa content increases when extracts are prepared. L-dopa converts into dopamine, an important brain chemical involved in mood, sexuality, and movement. Prozac (fluoxetine) is a selective serotonin reuptake inhibitor antidepressant, and affects chemicals in the brain. Interactions between the two have not been studied.

Answered 11/7/2015

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Dr. Pamela Pappas answered

Specializes in Psychiatry

Why do this?: Ground mucuna pruriens seeds have been used in ayurvedic medicine for parkinson's disease (pd). Studies show they contain l-dopa, and may provide advantages over standard l-dopa in pd. http://tinyurl.com/o8598e4 but you don't list parkinson's in your conditions, so why take it? There are no direct medicinal interactions, but serotonin and Dopamine interact in the nervous system. Steer clear.

Answered 4/26/2015

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Dr. Alan Ali answered

Specializes in Psychiatry

Marcana Puriens: I would not recommend it with antidepressants, as cases of High blood pressure & Nervousness & Seizures have been reported.

Answered 9/13/2019

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