How to tell if breast buds are to appear?and my nipples feel sensitive to the clothes i wear what does it signal?

You'll feel lumps: I am assuming you are taking feminizing hormone therapy, hopefully under supervision of a doctor! by starting estrogen therapy you stimulate the formation of breasts. Usually within a few months you will notice the nipples raising slightly and breasttissue develop. Nipple tenderness is very common just as when going trough puberty! there is some individual variation in when exactly this occurs.