A member asked:

Why is secondary igm deficiency seen in whipple's disease? i thought infection did not reduce immunoglobulin levels.

A doctor has provided 1 answer
Dr. Michael Ginsburg answered

Specializes in Interventional Radiology

Protein-losing Enter: Protein-losing enteropathy is characterized by excessive loss of serum proteins into the gastrointestinal tract. Lymphopenia is a common finding associated with protein-losing enteropathy due to whipple disease. In addition to the loss of albumin, components of lymph are also lost into the bowel, including lymphocytes, immunoglobulins, as well as fat-soluble vitamins, lipids & cholesterol.

Answered 7/4/2015

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