I take100mg topamax (topiramate) for migraine with 200mg seroquel topamax (topiramate) cuts my appetite when waking up i can't fall asleep easier should i take topamax (topiramate) earlier?

Depends : If topamax (topiramate) is keeping you awake, it certainly can be taken earlier. If your are on seroquel xr, you should take it earlier ( by 3-4hours) so it peaks and makes you sleepy at bedtime. If it is regular release, take it 1/2 to 1 hour before bedtime. If you are driving in the evening you should not take your medications until you are ready for bed. If this does not help, consider melatonin.