Can you take hydrocodone and zanaflex (tizanidine) together?

Yes: The only real issue is the sedative effects of both. Some people find that individually they are mild but together they make you very very sleepy. Also both can lower blood pressure so be careful when getting up from bed or a chair, you suddenly feel dizzy. This is called ortho static hypotension.

Yes : The drugs are often prescribed for concomitant use. As both can cause some sedation, be careful with the combination until you see how you respond.