HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

I take 50mg of zoloft (sertraline) in the morning and my dr. just prescribed tramadol for my torn shoulder. can i take these meds together?

A doctor has provided 1 answer
Dr. Brian Le answered

Specializes in Pain Management

Drug interaction: It is not recommended to mix tramadol with antidepressants such as zoloft (sertraline) due to increased risk of developing serotonin syndrome. Please talk to your doctor before taking these medications together.

Dr Refai agreed

Answered 12/10/2013

4.9k views

Thank
Show 3 more comments

Related Questions

A member asked:

I have tramadol for headaches, haven't used them in a while.Since then i started 100 mg of Zoloft (sertraline) for anxiety.Having bad aches today.Safe to take tram?

6 doctors weighed in across 2 answers

A member asked:

A doctor on here said that Zoloft (sertraline) can decrease the efficacy of Tramadol. If so what drug could I use instead, but not codeine ?

A doctor has provided 1 answer

A member asked:

I am on Zoloft (sertraline) for depression. Can I take a 50 mg tramadol for my broken foot?

2 doctors weighed in across 2 answers

A member asked:

Is a combination of meds like tramadol, amitriptyline and Zoloft (sertraline) better for controlling nerve pain than one of the meds alone ?

A doctor has provided 1 answer

A member asked:

Dr. Prescribed Ultram and Soma for chronic back pain, when needed, just recently he put me on zoloft (sertraline). Safe to take together or which combo to avoid.

6 doctors weighed in across 2 answers

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

Can you take zoloft (sertraline) in morning and tramadol in evening for knee injury?
Can i take zoloft, (sertraline) stribild, and tramadol together without any adverse reactions?
My psychiatrist prescribed me Zoloft (sertraline) and my family doctor gave me tramadol. Can those be mixed? I read on here that they can't be taken together?
Does Tramadol have as much SSRI in it as Zoloft (sertraline)? I take 100mg of Tramadol a day. Does 100mg of Tramadol have as much SSRI as say 50mg of Zoloft (sertraline)?
Will taking Tramadol interfere with my Zoloft (sertraline) withdrawal recovery, since it's an SSRI? I take only 2 Tramadol tabs a day. (Each tab is 50mg)

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.