Could someone take gabapentin while taking anti-depressants?

Yes, it is safe: Granted, Gabapentin does cause drowsiness, dizziness, and weight gain, which some anti-depressants cause, and the two together might make some of this worse, but Gabapentin has virtually no drug-drug interaction potential, and should really be very safe, if tolerated well.

Yes: In general, Gabapentin and anti-depressants have no significant drug interaction. However, they both can cause CNS depression. Also, you should check with your doctor before starting any new medication.