U.S. doctors online nowAsk doctors free
Dallas, TX
A 45-year-old female asked:

In your experience, how does lymphocytic hypophysitis evolve over time after initially causing permanent damage to acth-producing cells in the pituitary? does it continue to flare over the years?

3 doctor answers7 doctors weighed in
Dr. Susan Wingo
Endocrinology 34 years experience
Hypophysitis: Lymphocytic hypophysitismost often occurs in pregnant or recently delivered women. The inflammation is usually subacute, lasting for weeks-months, and has a fairly low risk of recurrence. However, hormone deficiencies caused by the inflammation are usually permanent. Destruction of acth-producing cells leading to low cortisol levels is the most common deficiency. Prolactin may be increased.
Dr. Jefferson Chen
Neurosurgery 35 years experience
Generally stabilizes: Generally, this seems to stabilize. However, most of the cases that I have seen are closely monitored by endocrinologists who follow the endocrinologic manifestations very closely. This is important as most patients need supplemental hormone therapy also. The rationale for the close follow-up is also to monitor for any flare-ups which may be suppressed quickly and efficaciously with medications.
Dr. Philip Kern
Endocrinology 44 years experience
Autoimmune disease: Other endocrine deficiencies can occur, such as tsh-hypothyroidism, so this needs to be followed. Like other autoimmune conditions, it can wax/wane, but usually causes progressive fibrosis and destruction of the pituitary.

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Educational text
Talk to a doctor
24/7 visits - just $39!
50% off with $15/month membership
Last updated Dec 13, 2020


Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.