Why would prostate levels jump from under 5 to 26.5 in 6 months: my uncle had prostate cancers few years ago and is 76 years old. bone scan is done?

Metastasis: With psa over 20, there is a strong possibility of metastatic disease. Absolutely needs a bone scan and urologic follow up.

Imaging Suggestions: A large and/or rapid increase in psa is concerning for potential recurrence or spread of prostate cancer. Further evaluation is suggested, potentially including a ct of the abdomen and pelvis and a whole body bone scan. If these tests are inconclusive, additional more specialized studies (e.g. A prostascint scan) may be valuable. Consultation with your urologist is the best place to begin.

The first step: Your first step is to consult with a urologist, who will recommend a biopsy. If the biopsy shows cancer, further imaging studies such as a ct and a bone scan will be needed. If the biopsy is negative, the psa test will need to be repeated at the least annually to determine the need for repeat biopsies.

A 5-fold: Increase in psa needs assessment. If his psa was 5 and he had prostate cancer, he may have been "watched & waited". First step, repeat psa; find out gleason score from prostate biopsy, get bone scan; ct abd/pelvis. Treatment depends on these results.