Probably safe: Melatonin is secreted by the pineal gland and helps regulate sleep\wake cycles. Use of suppliments appears safe, however studies of long term use are not currently availabe. No significant toxic effects have been found. There is some evidence of effects on bleeding and glucose tolerance. Care shoud thus be used in patients on blood thiners(aspirin, coumadin) and with diabetes.
Answered 2/21/2019
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