Is melatonin safe?

Generally yes: There are a number of cautions with the melatonin including be careful if you have a seizure disorder, glaucoma, hypertension, diabetes, depression, seizure disorder, or are taking an anticoagulant or have a coagulation disorder. It should not be taken during pregnancy or lactation. Liver dysfunction is another situation where caution is urged. People on medications that go through the cyp1a2 enzyme in the liver are to discuss this with their physicians before they take melatonin. In general it has an enhancing effect when taken with other sedatives including antihistamines.

Agree W Dr. Jacobsen: Concur that with the exceptions he listed that Melatonin is a safe approach to insomnia.