Depends: Often lymphocytic (microscopic) colitis may spontaneously regress and never need treatment. A low fat and low fiber diet can be tried first with symptomatic treatment of diarrhea with medications (like immodium or lomotil). Only more severe, persistent forms will need drug treatment just like other chronic inflammatory colitis.
Answered 6/9/2019
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See below: The first step in managing this disease is to stop nsaids (e.g. Ibuprofen) and all other offending agents (e.g. Omeprazole, sertraline). The drug of choice for treatment is Budesonide and an anti-diarrheal agent (loperamide). Other than that, gluten-free diet may be of some benefit.
Answered 6/24/2014
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