A member asked:

High blood cortisol levels but normal 24 hour free cortisol levels. what could this mean? ive had 2 blood cortisol tests which both came back high. the urine test was only done once. im waiting to do a saliva test next?

A doctor has provided 1 answer
Dr. Hiep Le answered

Specializes in Nephrology and Dialysis

High serum cortisol alone is not specific enough. The 24-hour urine collection for free cortisol is more valuable if it is appropriately collected. You should patiently wait for the bedtime salivary cortisol. If the bedtime salivary cortisol is also normal then either test can be repeated a second time for ruling out Cushing syndrome. Good luck.

Answered 9/9/2023

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