A 48-year-old female asked:
I had blood fasting cortisol test come back double normal amount. 24 hr urine test is within normal range. Why would it be different?
1 doctor answer
Dr. Melissa Young answered
8 years experience in Internal Medicine
24 hour -better test: The level of cortisol in the blood fluctuates during the course of the day and can spike from stress or pain (like getting your blood drawn), so a blood cortisol level tells us very little unless you are given a pill ahead of time to intentionally lower your cortisol and it stays high anyway. That is called a suppression test. We either use that or the 24 hour urine to screen for excess cortisol.
Answered on Jul 4, 2014
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