A member asked:

My doctor prescribed me sertraline hcl 100mg 1 a day and venlafaxine hcl 75mg 1 a day, but i'm reading here its not good to take both together, i have deppression and anxiety really bad for many years i feel sertraline is not working any more?

A doctor has provided 1 answer
Dr. Hiep Le answered

Specializes in Nephrology and Dialysis

You are correct because there is a major interaction when taking both together even both are not at maximal doses yet. I wonder if your doctor wants to replace sertraline with venlafaxine because sertraline is no longer effective. However, these 2 medications are at times used in combination but for your peace of mind you should call your doctor for confirmation. Good luck.

Answered Jun 25, 2023

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