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A member asked:
Can you develop resistance to ppi drugs after long years usage? omeprazole then lansoprazole and others no longer working?
2 doctors weighed in across 2 answers
PPI resistance has been described and is always possible, at this point revisiting with treating gastroenterologist is strongly recommended as an upper endoscopy may be needed.
Answered 6/20/2023
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It may not be a case of developing resistance to the medication, but that your acid reflux or whatever is causing your underlying symptoms is worsening. Regardless, it sounds as though a follow up visit to your gastroenterologist is in order to sort it out and get you on therapy that works for you. Good luck.
Answered 6/20/2023
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