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A member asked:
Can a igm kappa light chain monoclonal gammopathy turn into macroglobulinemia?
2 doctors weighed in across 2 answers
IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin.
Answered 8/16/2018
5.2k views
Yes: Dr. Singh is absolutely correct that this is not standard terminology. I'm wondering of you have perhaps been told that you have monoclonal gammopathy of uncertain significance and the paraprotein is an igm with kappa light chains. This is quite common and does sometimes become waldenstrom's or cll or lymphoma but with only ~1.5% chance per year. Good luck, easy does it.
Answered 2/13/2019
5.2k views
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Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow
5 doctors weighed in across 2 answers
A member asked:
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.
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Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?
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