A member asked:

Is it possible to have ms and no lesions are found on an mri? if suspecting ms still what would be the next step?

4 doctors weighed in across 2 answers

Yes: Because MRI is particularly useful in detecting central nervous system demyelination, it is a powerful tool in helping to establish the diagnosis of ms. It should be remembered, however, that approximately 5% of patients with clinically definite ms do not show lesions on MRI at the time of diagnosis. Ms remains a clinical diagnosis with MRI but one tool in its diagnosis and management.

Answered 4/14/2017

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Would be unusual: But have seen patients who lack brain lesions and spots are within spinal cord, so may need cervical MRI to make certain of diagnosis. If there are uncertainties, might do lumbar puncture, and also blood studies to rule out other causes which could mimic MS

Answered 4/14/2017

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