Can you take 1 norco 7.5/325 and tizanidine 4 mg together?

I would go to Drugs.com and enter both meds and all others you are taking into their interaction checker and see. The 325 is aspirin. And then discuss with you Dr who will know your kidney and liver function.

Caution is recommended as both drugs are central nervous system depressants. In practice they are many times used together for short periods of time and if tolerated. Your prescriber remains your best reference at this point.