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A 44-year-old female asked:
Left thyroid nodule (2.5). fna cytology shows cellular follicular lesion suggestive of neoplasm, oncocytic type. then further afirma testing shows bethesda iv and benign. dr says not cancer. is the afirma accurate? should i be worried?
2 doctor answers • 3 doctors weighed in

Dr. Hiep Leanswered
Nephrology and Dialysis 44 years experience
Yes, your nodule is likely not cancerous, i.e. benign. Pathology is read as follicular neoplasm (Bethesda IV) which has the risk of malignancy of 25-40% so thyroidectomy is usually recommended in the past but this practice has changed with molecular testing (Afirma) which only miss 3% of malignant cases if test is (-). You will have a follow-up ultrasound in 1-2 years for making sure no change.
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Answered Jun 13, 2022

Dr. Sewa Leghaanswered
Medical Oncology 52 years experience
Your Thyroid has a Nodule which on biopsy is bordering on being Cancerous.
Under your circumstances, I would advise you to get it removed surgically. The final diagnosis will remain ambiguous until your have had a good pathology examination from the fully removed Nodule. It will likely require a partial thyroidectomy.
Created for people with ongoing healthcare needs but benefits everyone.
Reviewed Jun 26, 2022
Last updated Jun 26, 2022
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