U.S. doctors online nowAsk doctors free
A 44-year-old female asked:

Left thyroid nodule (2.5). fna cytology shows cellular follicular lesion suggestive of neoplasm, oncocytic type. then further afirma testing shows bethesda iv and benign. dr says not cancer. is the afirma accurate? should i be worried?

2 doctor answers3 doctors weighed in
Dr. Hiep Le
Dr. Hiep Leanswered
Nephrology and Dialysis 44 years experience
Yes, your nodule is likely not cancerous, i.e. benign. Pathology is read as follicular neoplasm (Bethesda IV) which has the risk of malignancy of 25-40% so thyroidectomy is usually recommended in the past but this practice has changed with molecular testing (Afirma) which only miss 3% of malignant cases if test is (-). You will have a follow-up ultrasound in 1-2 years for making sure no change.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Sewa Legha
Medical Oncology 52 years experience
Your Thyroid has a Nodule which on biopsy is bordering on being Cancerous. Under your circumstances, I would advise you to get it removed surgically. The final diagnosis will remain ambiguous until your have had a good pathology examination from the fully removed Nodule. It will likely require a partial thyroidectomy.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Jun 26, 2022


Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.