I’ll presume this regards IBS-D type, a challenging chronic illness. I strongly advise a multi-treatment approach. I would stay recommend Imipramine at 10 mg (this dose should be well tolerated), add an antispasmodic such as hyoscyamine for acute pain, be very careful with diet, and perhaps add peppermint oil as a supplement. Many also find a bulking agent like MiraLax beneficial.
Answered 2/24/2022
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